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Undoubted drug-resistant tuberculosis treatment: Scientists want to restore the effectiveness of the antibiotic



  Reviving drug-resistant tuberculosis treatment: Scientists seek to restore antibiotic efficacy

The cause of tuberculosis (TB) is the "Mycobacterium tuberculosis bacterium". In the body, the bacterium turns into a harder form that is harder to kill and endures more stress.

Drug-resistant tuberculosis: Researchers have found a compound that fights and even reverses resistance to a widely used antibiotic used to treat tuberculosis, the world's deadliest disease.

The increasing increase in drug-resistant tuberculosis is a major obstacle to successfully treating the disease. In 201

7, approximately 1.5 million people died of tuberculosis, making it the deadliest infectious disease in the world.

Washington University researchers in the United States and Umea University in Sweden reversed resistance to isoniazid, the most widely used antibiotic for the treatment of TB. The study, published in the journal Proceedings of the National Academy of Sciences, was conducted on microorganisms growing in the laboratory and served as the basis for future human and animal studies.

The use of the compound in combination with isoniazid could potentially restore the influence of the antibiotic in people with drug-resistant TB. The compound can also help the antibiotic kill tuberculosis bacteria, even if they are sensitive to drugs. This implies that physicians could now think about reducing the annoying six-month medical treatment they are prescribing today.

An associate professor at Washington University, Christina Stallings, says that it is very difficult for people to comply with such a long procedure. According to Stallings, the longer a person has to take antibiotics, the more problems he will face with patient compliance. It can also lead to treatment failure and drug resistance.

Christina added that they have found a compound that sensitizes bacteria for an antibiotic. It reverses the drug resistance and prevents its formation (at least in the laboratory). She mentioned that if they can turn this compound into a drug for humans, it could make their current therapies more effective, which can be beneficial in fighting this pandemic.

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Instead of searching for better and more effective antibiotics, scientists looked for compounds that prevent the bacteria from getting worse , In a low-oxygen environment, tuberculosis bacteria are found in the body. The bacteria come together to form a thin film called biofilm. This biofilm not only resists low oxygen conditions, but also antibiotics and other stressors.

The team studied 91 compounds that shared a common chemical core structure that restricted biofilms in other bacterial species. The scientists found a compound called C10, which prevented the formation of a biofilm by bacteria. However, it did not kill the TB bacteria.

Further analysis revealed that blocking biofilm formation with C10 facilitates the killing of bacteria with antibiotics. It has even slowed down the development of antibiotic resistance. The scientists needed only a fraction of the amount of isoniazid to kill the tuberculosis bacteria when C10 was present, as with isoniazid alone.

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In addition, one out of every one million TB bacteria becomes spontaneously resistant to isoniazid when grown under typical laboratory conditions , However, the drug-resistant bacterial mutants never occurred when the scientists bred with isoniazid and the compound TB bacteria.

Stallings said that combining C10 with isoniazid could increase the efficacy of the antibiotic and prevent TB bacteria from developing drug resistance. She said that it means that she might be able to shorten the treatment process. However, Stallings warned that the compound is not suitable for animal testing or even for human use.

This research has been carried out on bacteria that grow in a laboratory. Scientists are still considering whether the compound is safe and how it could be processed by the body.

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Posted by: Onlymyhealth Staff Writer

Source: Onlymyhealth Editorial Team 06 June 2019


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