Phosphatidic Acid (PA)
This molecule is a phospholipid that regulates mTOR (the mammalian target of rapamycin). Simply put, when you control mTOR, you control the switch that turns on muscle protein synthesis in response to the workout. "One" means muscle. "Off" means no muscle. It's as simple as that. It's naturally present in the diet, but only in very small, insignificant amounts.
A study of 16 weight lifters revealed that 750 mg. of PA increased squat 1RM and body mass. Another, also with 750 mg. (Divided into two doses, one before lifting and one after the other) in 28 weight lifters found that the PA group gained 2.4 pounds more muscle than the placebo group. Another study found that lower doses of PA (250 mg and 375 mg) increased muscle mass and cross-sectional area of the rectus femoris in another group of 28 men.
The Bioavailability Issue
In order for PA to function, it must penetrate the muscle cell and bind to mTOR. It can also work indirectly by conversion to lysophosphatidic acid and attachment to the muscle membrane, thereby increasing intracellular PA and activating mTOR.
However, different PA sources may have different levels of saturated or unsaturated fatty acid chains. This affects the functioning of PA. Two saturated fatty acids do not promote mTOR signals, but one saturated and one unsaturated fatty acid.
Chemi Nutra, one of the country's most innovative material manufacturers, has developed an unsaturated form of PA. This means that it is orally absorbed with high bioavailability, resulting in an 8-fold activation of mTOR lasting about 7 hours.
Therefore, you should only use PA supplements that come from Chemi Nutra, such as Micro-PA®. [1
6 additions to essential supplements
Further information on Micro-PA®