I was there when EAS introduced HydroxyMethyl Butyrate, better known as HMB, to the world. I had nothing to do with the actual research, procurement, manufacturing, or anything else if you were to introduce a new supplement to the world, but I was there as editor-in-chief of the company's journal. Muscle Media 2000 (MM2K).
To my great embarrassment, however, I am partly responsible for the unofficial marketing slogan they used: "Feels like Deca" (as in Deca-Durabolin, the anabolic steroid), but hear me out. I can explain it (sip).
The company boss, Bill Phillips, had sent several HMB samples to various consultants and friends to receive submissions prior to product release. I was at a spontaneous meeting in his office when I saw a fax on his desk. It was from the notorious, now-defunct steroid expert Dan Duchaine. The fax referred to HMB, and on the edge of Dan's handwriting, the words were, "This stuff feels like Deca!"
Dan was not usually a horseshoe or an exaggeration, so I said to Bill, "Hell, that's how you should market HMB!" And so it happened.
Although it would have broken all sorts of FDA rules to put it on the label, "Feels Like Deca" has been included in articles about the product and maybe even one or two ads. This unofficial slogan is still mockingly surfaced in various Internet threads and is usually greeted with a mocking mockery.
I'm really sorry for all that. Let me now say that if you are not suffering from AIDS, cachexia or ridden in bed due to an indescribable illness, HMB has never been like Deca and it still is not.
HMB research shows
HMB is a metabolite of the amino acid leucine. When you take leucine, about 5% of it is converted to HMB and it seems quite convincing that HMB has a stronger effect in preventing muscle breakdown than actual leucine, at least in elderly or sick people.
There is little evidence that it is better than leucine in muscle protein synthesis. One study found that 3.42 grams of HMB (3 grams is the standard, recommended dose) increased muscle protein synthesis by 70%, while leucine itself increased it by 110% (1).
Another study that used athletes found that HMB increased muscle mass by 0.2 ± 2.2% over the course of 9 weeks, which did not mean much, as participants also increased their food intake by 8% (2). In all likelihood, they only ate for a few weeks.
The most recent literature-published study published last month also found that supplementation with HMB "did not improve body composition more than placebo" (3). , "
Almost all other studies point to either failures or middle to middle scores, but even those who promised a lot were confused by debilitating factors (an increase in calories, protein, or unpublished, but nutritional)
HMB is a bit shimmering, preventing muscle wasting, especially in old age, or in people who suffer from AIDS, cachexia or generally bedridden.
Studies to see if it works The muscle protein degradation However, preventing athletes is very low and probably not relevant to weightlifters.A representative study to examine the effects of HMB in preventing athlete loss (judo) in severe calorie restriction found that the dietary supplement worked equally well like placebo (4).  HMB will probably not bring anyone to read If you are feeling particularly sensitive to the placebo effect, it certainly does not work like Deca.
It may be best for people to recover from illness, injury or surgery, which is why Ensure producers, who make diet shakes primarily for old coots, are probably the cause (if not theirs stated goal, this is certainly its main demographic principal by turnover). have included HMB in at least one of their formulas.
Lifters and athletes interested in promoting additional muscle protein synthesis or preventing muscle breakdown would be better placed to consume whole proteins with high protein efficiency, such as micellar casein, a whey isolate, or a mixture of the two ,
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- Wilkinson, DJ et al., "Effects of leucine and its metabolite, b-hydroxy-b- methylbutyrate (HMB) on human skeletal muscle metabolism, Journal of Physiology, 2013.
- Thomson, JS et al., "Effects of nine-week beta-hydroxy-beta-methyl butyrate supplementation on strength and body composition in resistance-trained men J. of Strength and Conditioning Research, 2009.
- Felipe Texeiria et al., "No effect of HMB or α-HICA supplementation on exercise-induced changes in body composition", European Journal of Nutrition, 27. December 2018.
- Hung, Wei et al B-hydroxy-b-methyl butyrate supplementation with energy restriction in female judo athletes, "Journal of Exercise Science and Fitness, Full 8, Issue 1, June 2010.