From historical accounts, we know that ancient people and lesser peoples frequently used plants and herbs to treat disease. Through years of trying out, they were able to find out which plants had healing powers.
They had probably encountered plants that had high concentrations of certain natural phenolic compounds, commonly referred to as polyphenols.
However, institutionalized medicine did not pay much attention to them, because the things these healers used simply did not work well enough to spark interest or confidence. No amount of abominable-tasting herbal teas would cure diabetes, lower body fat, or prevent heart disease.
But since then, science has been able to identify, extract, concentrate, and use these herbal chemicals in a way that would make it proud of all these old folk physicians.
The most common examples of these polyphenols include resveratrol, green tea extract, quercetin, caffeic acid, anthocyanins such as cyanidin-3-glucoside, and the current darling of the polyphenol world, curcumin. [1
What dosage does Fisetin have?
Like many polyphenols, Fisetin seems to be a commodity that plays shortstop on nutrition as well as it does in terms of diet field. One problem – though more than 800 Fisetin studies have been done, only one of them affected humans. Most of what we know is based on experiments with mice and rats.
If some of the following benefits extend to humans, as they often do with polyphenols in general, then we might actually have something:
- Reduces the body fat: Mice increased 75% less, when they were on a high-calorie diet and treated with fisetin. It is believed that fisetin may increase the level of the fat burning hormone adipokinectin.
- Helps regulate blood sugar: Diabetic rats and mice given fisetin had insulin and blood sugar levels that are compatible with healthy mice. In addition, it prevented the binding of sugar to proteins, a process known as glycation that contributes to a variety of harmful substances such as nerve damage, kidney disease, cataracts and the aging of tissues in general.
- Prevents the growth of various cancers: Like curcumin, fisetin seems to hate cancer and is particularly prone to colon, brain, lung, breast, ovarian, pancreatic and brain cancers. It also appears to protect against prostate cancer by blocking the receptors for DHT.
- Improves memory and learning ability: Fisetin improved the memory and learning ability of old rats.
- Protects the Skin: Fisetin slows down the breakdown of collagen in cells exposed to ultraviolet light.
- Relieves depression and anxiety: Fisetin appears to increase serotonin and norepinephrine levels, thereby improving mood.
- Helps to ameliorate neurodegenerative diseases: Alzheimer's disease, Huntington's disease, multiple sclerosis or amyotrophic lateral sclerosis showed marked improvements in memory, balance, coordination and longevity when fisetin was introduced.
- Lowers Blood Pressure: Fisetin dilates the blood vessels, releasing blood to flow more easily through the tubes.
- Helps to better manage alcohol: Mice that celebrated too hard were able to process alcohol.
- Combating Irritable Bowel Disease (IBS): When mice were administered Fisetin with the human equivalent of IBS, the inflammation went back far "senolytically" as it helps the aging body move away from senescent cells (cells that are no longer sharing) that normally cause inflammation and shortened life when left to care.
How does Fisetin work?
Like most polyphenols, fisetin is a powerful antioxidant that explains or partially explains many of its effects.
Second, it blocks an inflammatory switch known as NF-kB. Blocking this protein complex can thwart the evil plans of cancer, allergies, and autoimmune diseases.
Fisetin also affects mTOR, a kinase that acts as a kind of cellular switch. Higher post-workout mTOR levels are a good thing as they promote muscle growth. However, a persistently high level of mTOR is associated with a variety of diseases. Fisetin could be used to modulate the mTOR values to your advantage.
Is Fisetin safe?
Fisetin, like most polyphenols, only seems to have better angels on its shoulders, as it has no negative side effects, even in high doses (at least in animal studies).
Pregnant women and children should nevertheless follow the usual warnings, as we do not know enough about the substance. The good news is that the Mayo Clinic is currently investigating Fisetin in three separate studies dealing with diabetes, kidney disease and frailty. Therefore, we should soon receive more information about its safety and effectiveness.
What Foods Contain Fisetin
Of all the foods analyzed for fisetin levels, strawberries contained the most, but you would need to eat about 37 of them daily to achieve the improved kidney function seen in a mouse study.
Taking Fisetin as a nutritional supplement is more realistic and there are currently some offers on the market, but we are not quite sure which dosages are optimal for human health.
The aforementioned Mayo Clinic trials use dosages of between 1,000 and 1,000, 2,000 mg. Every day, what a hell of a lot. However, in the one human study currently published in the literature, it is only 100 mg. One day has been shown to be effective in reducing inflammation in cancer patients.
To make things even more complicated, Fisetin, like many polyphenols, is poorly absorbed. However, taking fish oil or olive oil can help bring it into your system.
Of course, it was not known from the outset to combine curcumin with piperine or cyanidin-3-glucoside with a self-emulsifying delivery system to improve their bioavailability. Science will undoubtedly unlock the key to the absorption problems of Fisetin.
Follow the polyphenol diet, become immortal
Curcumin – the next major superfood
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- Paul Hunter, "13 Amazing Fisetin Benefits and Foods, Dosage and Side Effects," Selfhacked, June 8, 2019.
- Paul Robbins, PhD. "An aging superstar you should know", Bottomline Health, July 2019, Vol. 33 / No. 7
- Park JM1, Lee JH1, Na CS2, Lee D3, Lee JY4, Satoh M4, Lee MY1. "Heartwood extract from Rhus verniciflua Stokes and its active ingredient fisetin mitigate vasoconstriction through the calcium-dependent mechanism in the rat aorta", Biosci Biotechnol Biochem. 2016; 80 (3): 493-500.
- Prasath GS1, Subramanian SP. "Modulatory effects of fisetin, a bioflavonoid, on hyperglycemia by attenuation of the key enzymes of carbohydrate metabolism in liver and kidney tissues in streptozotocin-induced diabetic rats", Eur J Pharmacol. 2011 Oct 15; 668 (3): 492-6.
- Nathan K. LeBrasseur, 1.2 Tamara Tchkonia, 1 and James L. Kirkland1. "Cellular Senescence and the Biology of Aging, Illness and Infirmity", Nestle Nutr Inst Workshop Ser. 2015; 83: 11-18.