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Cannabidiol (CBD) stores are basically the 2020 version of frozen yogurt joints that appear on every street corner. With miracle claims in all interwebs, it is difficult to separate science from hype. And if you live with inflammatory bowel disease (IBD), it is literally worthwhile to examine everything that could help alleviate the symptoms.
Researchers were particularly excited to find out whether this cannabis-based compound, due to its inflammatory effects, can help people with IBD have anti-inflammatory potential.
Could CBD bring relief without the downsides? While many theorize about its anti-inflammatory properties, few small studies have been done.
Previous research results:
- Several studies have shown that CBD can relieve bowel inflammation (at least in mice). This could be because CBD is an antagonist for a receptor responsible for inflammation.
- In a study in mice from 2016, a cannabis extract with a high CBD content reduced intestinal damage caused by colitis and reduced hypermotility (overactive intestine). The extract was more effective than pure CBD and helped include other chemicals from the cannabis plant.
- CBD can also help to maintain a healthy intestinal barrier.
- On the other hand, in a small study from 2017, 19 participants with Crohn's disease who took 10 milligrams of oral CBD twice a day for 8 weeks showed no improvement. However, it has been found that the CBD is safe and well tolerated.
- In a study from 2018 on 60 people with IBD, taking 50 milligrams of botanical extract with a high CBD content twice a day did not lead to remission but improved the quality of life.
CBD comes in many forms, strengths and combinations. It is therefore helpful to know what you are looking for.
CBD products can be divided into three categories:
- Full spectrum: contains CBD, different amounts of THC, other cannabinoids, terpenes and flavanoids – all natural components that were obtained from the cannabis plant
- Wide range: contains CBD, other cannabinoids, terpenes and flavanoids, but THC removed
- CBD isolate: contains only CBD with none of the other cannabis chemicals.
Once you've chosen a CBD type, it's time to consider all the ways you can consume or use it:
- Oils, tinctures, and sprays are quickly applied either under the tongue or over the Mucous membranes of the nose.
- Capsules and soft gels contain CBD oil, but act more slowly because they are absorbed through the digestive system.
- Edibles are usually approx. Ndy or baked goods with CBD.
- Steam oils are inhaled through vaporizing sticks and are the quickest to get into the bloodstream via the lungs.
- Suppositories are applied internally to the rectum or vagina.
- Topical products (lotions, creams and ointments) are most often used for localized pain or skin diseases.
- Transdermal patches deliver CBD through the skin for another localized option.
- A CBD-based prescription drug, Epidiolex, was approved by the FDA in 2018 for the treatment of severe epilepsy.  A review of CBD research in 2019 analyzed the dosage used in studies and found a wide range from 1 to 50 milligrams per kilogram of body weight per day. IBD studies from the same overview used 20 and 50 milligrams of CBD per day.
In general, studies with higher doses had more positive results. However, more research is needed to determine effective CBD doses for different conditions.
To determine the dosage, you should know your weight in kilograms and the CBD concentration in the product you have selected. Start with a low dose and slowly increase it to find the lowest amount that will have the desired effect.
The FDA warns consumers of these risks associated with using CBD:
- CBD can harm your liver.
- 19659008] CBD can interact negatively with other drugs, especially drugs that are processed by the liver.
- The simultaneous use of CBD with alcohol or sedatives can cause drowsiness and lead to injuries.
- The use of CBD can increase blood. Thinning effects of the drug warfarin (also known as Coumadin).
- Animal toxicity has shown reproductive toxicity and reduced fertility in offspring.
Because CBD products are not regulated by the FDA, labels may not show exact amounts of CBD, THC, other chemicals, and pesticides. So be careful when trying CBD.
Taking CBD does not make you feel high unless the product also contains significant amounts of THC. Every legal CBD product should be clearly labeled with the content of CBD and THC, if it is present.
In the 2018 study mentioned above, 90 percent of the participants had adverse effects from taking a botanical extract with a high CBD content. The most commonly reported side effect was dizziness.
The FDA also lists these side effects for CBD:
- gastrointestinal problems such as diarrhea or reduced appetite
- mood swings such as irritability or arousal
In 2018, the researchers carried out relevant studies on the use complementary and alternative therapies to relieve the symptoms of inflammatory bowel disease. They found that up to 60 percent of IBD patients use complementary and alternative therapies.
Here are the research highlights:
- Probiotics can help patients achieve and maintain remission of ulcerative colitis (UC).
- Curcumin (a component of spice turmeric) can also help people with UC due to its anti-inflammatory properties.
- Acupuncture and moxibustion can improve UC and Crohn's disease in combination with conventional treatment.
- Cognitive behavior therapy improves quality of life and reduces depression and anxiety in people with IBD.
- Mindfulness practice also improves quality of life and reduces depression and anxiety.
- Hypnotherapy can prolong the remission of UC.
- Yoga improves the quality of life and reduces abdominal pain and anxiety.  Sport improves quality of life, bone mineral density and the relapse rate.
If you have been diagnosed with IBD, you should receive regular care from a doctor o can help you treat symptoms and monitor changes in your condition. Talk to your doctor before trying CBD or other alternative IBD remedies.
If you experience symptoms of IBD, contact a doctor for diagnosis. IBD is diagnosed using a combination of scoping techniques to examine the GI tract and imaging, such as X-ray, MRI, or CT scans. Stool and blood tests may also be required.
It looks like the United States is on the right track to finally release weeds. Given the stricter regulations for cannabis-derived CBD products, researchers want to find out how the chemical can be used to treat a wide range of diseases.
CBD is traditionally considered to be anti-inflammatory, which is why its use is particularly interesting for people living with inflammatory bowel diseases. While CBD is generally considered safe for adults, research on its use in IBD has given mixed results.
Talk to your doctor and find out about the latest research (which is rapidly being introduced) on how CBD can make life easier with IBD.